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An Introduction to Medicinal Chemistry (7th edition)
An Introduction to Medicinal Chemistry (7th edition)

An Introduction to Medicinal Chemistry (7th edition)

著者: 
Graham L. Patrick
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  • The author's renowned clarity of writing and the book's logical structure help to address the challenges of teaching and studying Medicinal Chemistry.
  • New chapters on Protein Kinase and Antibodies provide insightful, up-to-date coverage of some of the most significant topics in the subject today
  • The pedagogical features enhance student engagement, which supports better knowledge retention, and a more confident application of concepts and ideas to unfamiliar problems.
  • Boxes and case studies support a real-life applied approach that helps lecturers to show how theoretical content relates to the practical reality of medicinal chemistry.
  • Full-colour images throughout the new edition enhance the student experience by helping them to better visualise the concepts presented.
  • New and updated exercises, questions, and activities throughout the book and online help students to hone their problem-solving skills.

New to this Edition:

  • Newly added high-level Multiple-Choice Questions to support self-directed learning and challenge the understanding of the processes and concepts covered
  • Updated and new Protein Data Bank Exercises available online.

  
Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? What's the process behind drug discovery? How do our bodies interact with those chemicals?
  
An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding.
  
The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E.
  
From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success.
 

目次: 

1:Drugs and Drug Targets
2:Protein Structure and Function
3:Enzymes: Structure and Function
4:Receptors: Structure and Function
5:Receptors and Signal Transduction
6:Nucleic Acids: Structure and Function
7:Enzymes as Drug Targets
8:Receptors as Drug Targets
9:Nucleic Acids as Drug Targets
10:Miscellaneous Drug Targets
11:Pharmacokinetics and Related Topics

    Case Study 1:Statins

12:Drug Discovery: Finding a Lead
13:Drug Design: Optimizing Target Interactions
14:Drug Design: Optimizing Access to the Target
15:Getting the Drug to Market

    Case Study 2:The Design of ACE Inhibitors
    Case Study 3:Artemisinin and Related Antimalarial Drugs
    Case Study 4:The Design of Oxamni
    Case Study 5:Fosfidomycin as an Antimalarial Agent

16:Combinatorial and Parallel Synthesis
17:In Silico Drug Design
18:Quantitative Structure-Activity Relationships

Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor

19:Antibacterial Agents
20:Antiviral Agents
21:Anticancer Agents
22:Protein Kinase Inhibitors as Anticancer Agents
23:Antibodies and Other Biologics
24:Cholinergics, Anticholinergics, and Anticholinestarases
25:Drugs Acting on the Adrenergic Nervous System
26:The Opioid Analgesics
27:Anti-Ulcer Agents
28:Cardiovascular Drugs

    Case Study 7:Steroidal Anti-Inflammatory Agents
    Case Study 8:Design of a Novel Antidepressant
    Case Study 9:The Design and Development Of Aliskiren
    Case Study 10:Factor Xa Inhibitors
    Case Study 11:Reversible Inhibitors of HCV NS-34A Protease

著者について: 

Graham L. Patrick, Associate Lecturer, University of the West of Scotland
   
Dr Graham L. Patrick gained his BSc Honours at Glasgow University, winning the McKay-Smith Prize for Chemistry. He completed his PhD with Professor Kirby and Professor Robins studying the biosynthesis of gliotoxin and related fungal metabolites. Following this, he worked in the pharmaceutical industry as a research chemist and radiochemist on a variety of projects that included topic areas such as opioids, antibacterial agents and antidepressants. His academic career has included positions at Leeds and Strathclyde Universities as well as the Australian National University. He joined the University of Paisley (now the University of the West of Scotland) in 1990, teaching medicinal chemistry and drug design. Currently, he is an Associate Lecturer with the Open University, an author of scientific textbooks and fiction, and an historical archivist.

"The best general undergraduate textbook on medicinal chemistry. This new edition retains the accessible style of writing, but provides important updates on the topics." - Dr Mark Ashton, School of Pharmacy, Newcastle University, UK
   

"I read this masterpiece to build a strong knowledge of medicinal chemistry and it has helped me a lot. I would definitely recommend it to others. Detailed explanations of enzyme-substrate interactions and much more are very useful." - Jinkal Gondaria, MChem student, Manchester Metropolitan University, UK
    

"A very useful medical chemistry book and teaching tool. Great learning resources and easy to digest content." - Dr Silvia M.M.A. Pereira-Lima, Department of Chemistry, University of Minho, Portugal

商品情報

ISBN : 9780198866664

著者: 
Graham L. Patrick
ページ
960 ページ
フォーマット
Paperback
サイズ
219 x 276 mm
刊行日
2023年03月
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An Introduction to Medicinal Chemistry (7th edition)

An Introduction to Medicinal Chemistry (7th edition)

An Introduction to Medicinal Chemistry (7th edition)